SYNCRIP and spinal muscular atrophy: Furthermore, separate studies have revealed that SYNCRIP binds with wildtype Survival of Motor Neuron (SMN) protein, but not the truncated or mutants forms found in Spinal Muscular Atrophy (Rossoll et al., 2002), and Syp genetically interacts with Smn mutations in vivo (Sen et al., 2013).