The overabundance of the minor IGHV5 subgroup in the IgE repertoire has been suggested to associate with the pathogenesis of allergic disease,6, 8, 12 as previously demonstrated by comparing IgE and IgM repertoires within allergic subjects.6, 7 However, our results suggest that the overabundance of IGHV5 might be specific to IgE but not to allergy per se. This evidence concerns the gene IGHE and allergic disease.