FGFR3 and breast carcinoma: FGFR gene amplification is frequent in breast cancer, gastric cancer and lung cancer etc. In contrast to the activation of FGFR3 and FGFR4 by mutation [2], [3], amplification of FGFR3 and FGFR4 has been described only rarely in cancer and no data related to prognosis could be obtained.