Our more recent studies demonstrated that diacylglycerol kinase zeta, which catalyzes DAG, rescues HF [2] and inhibited atrial [3] and ventricular [4] arrhythmias in Gαq-TG mice, suggesting that DAG plays a critical role in the development of cardiac hypertrophy and HF in this mouse model. Here, DGKZ is linked to hydrops fetalis.