Therefore, the aim of this study was to estimate the effect size of PNPLA3 148M/M on fibrosis progression rate (FPR) and the interaction with age at infection in a unique validated cohort of 247 CHC subjects without significant alcohol intake and diabetes, characterized by a careful estimation of age at infection and with histological determination of liver damage [3]. This evidence concerns the gene PNPLA3 and fibrosis.