However, overstimulation of AA leads to increase in its metabolites COX-2 and PGE2[36], [37], and subsequently decreased the level of 15d-PGJ2 and 14-3-3 ζ/δ, which may play a vital role in immune dysfunction and disease progression [38], [39] in HAD patients [26]. Here, PTGS2 is linked to immune system disorder.