Overall, the data provide evidence of an interaction of cocaine use and HIV infection leading to an association between AA and its metabolites COX-2, TBXA2 R and 5-LOX by increasing the levels of PGE2, and formation of neurotoxin AA subsequently reducing the levels of 15d-PGJ2 and 14-3-3 ζ/δ in HIV positive cocaine users. Here, ALOX5 is linked to HIV infectious disease.