With regard to IL-27 polymorphisms, previous studies have demonstrated that -964 A/G polymorphism of the IL-27 gene and the haplotypes of -964 A/G, 2905 T/G, and 4730 T/C were associated with the susceptibility to IBD,12 asthma,10 and COPD.11 However, in the setting of tumors, no associations were found with respect to esophageal cancer,13 nasopharyngeal carcinoma,14 glioma,15 and hepatocellular carcinoma.26 Our results were in agreement with the results of studies on the tumors. This evidence concerns the gene IL27 and esophageal cancer.