Previously, studies have investigated the association between IL-27 gene polymorphisms and several tumors, such as esophageal cancer,13 nasopharyngeal carcinoma,14 glioma,15 and colorectal cancer.16 However, little is known about the role of IL-27 gene polymorphisms in the carcinogenesis of osteosarcoma. This evidence concerns the gene IL27 and esophageal cancer.