IL27 and osteosarcoma: With respect to the IL-27 polymorphism with serum IL-27p28 levels, although serum IL-27p28 levels were lower in osteosarcoma than in controls, we did not found any differences between serum IL-27p28 levels and IL-27 gene -964 A/G, 2905 T/G, and 4730 T/C polymorphisms, which was similar to what Zhao et al15 reported, suggesting that the above 3 variants may not influence the production of IL-27p28 levels.