As overexpression of Angptl3 down-regulates Ikaros in HSCs [27], and since Ikaros deletions are frequently observed in B-cell acute lymphoblastic leukemias [53], this may provide an alternative explanation for the reduced circulating mature B-cells following transplantation of Angptl3-overexpressing HSCs. This evidence concerns the gene IKZF1 and B-cell acute lymphoblastic leukemia.