We also confirm, using the aortic ring assay and the chicken embryo CAM xenograft model, that the increase of VEGF, MMP-2 and MMP-9 expression mediated by LOX-1/oxLDL has a tumoral angiogenic effect both in vivo and ex vivo on C4-2 prostate cancer cells models. The gene discussed is MMP9; the disease is Familial prostate cancer.