INS and obesity due to melanocortin 4 receptor deficiency: The second phase of inflammation in the muscle and WAT causes a more intractable and persistent inflammation which is probably linked to lipid overload and lipotoxicity in WAT and muscle [38] Nonetheless, it remains to be seen how the first phase in inflammation and glucose intolerance contributes to the subsequent development of obesity and insulin insensitivity and whether strains of mice that are less susceptible to a HF diet also mount such a response.