INS and hydrops fetalis: Nonetheless, studies of early responses to a HF diet are emerging with one study showing that insulin insensitivity after 1 week of HF diet in the C57Bl/6 mouse is the consequence of insulin insensitivity in the vascular endothelium [13], and another demonstrating that hypothalamic markers of inflammation are activated between 1 and 3 days on a HF diet [14].