The expression of acute phase protein genes in the liver on the HF diet was elevated for serpinA3N (the gene encoding aACT) at 3 days, 1 week and 16 weeks, haptoglobin at 1 week and 16 weeks and serum amyloid A at 3 days and 1 week, however, the level of up-regulation varied (Fig 9A–C). Here, HP is linked to hydrops fetalis.