VIM and nonpapillary renal cell carcinoma: However, ccRCC has other evidence to suggest an intrinsically mesenchymal phenotype, such as its uniformly high expression of mesenchymal marker vimentin, lack of expression of epithelial structures such as cilia [33] and its propensity for differentiation along mesenchymal lineages as reported by Tun et al who demonstrated adipogenic and osteogenic transdifferentiation of ccRCC in vitro[34].