RELA and cholangiocarcinoma: Fig. 1A shows the immuno-stainings of p65 as a representative of NF-κB subunit expression in liver tissues from cadaveric donors and CCA patients. Normal bile duct epithelia of CCA patients and cadaveric donors did not express any NF-κB subunits. In contrast, all NF-κB subunits were frequently and strongly expressed in the cytoplasm of hyperplastic/dysplastic and CCA bile duct epithelia (Fig. 1B).