The tight correlation between TG2 expression/activation and constitutive activation of NF-κB in PaCa cells and many other cancers [61], warranted our attention to address the question whether 5-HT1B/1D receptors-activated proliferation/invasion signaling pathways is mediated through TG2 and/or NF-κB. This evidence concerns the gene TGM2 and permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.