The tight correlation between TG2 expression/activation and constitutive activation of NF-κB in PaCa cells and many other cancers [61], warranted our attention to address the question whether 5-HT1B/1D receptors-activated proliferation/invasion signaling pathways is mediated through TG2 and/or NF-κB. The gene discussed is NFKB1; the disease is cancer.