We also investigated the regulatory effect of type 1 diabetes on the transcription of genes related to inflammation such tumor necrosis factor-alpha (TNFα), interleukin-6 (IL6), monocyte chemotactic protein 1 (MCP1) and plasminogen activator inhibitor 1 (PAI1) (Figure 4). This evidence concerns the gene CCL2 and type 1 diabetes mellitus.