Since the differential expression levels of the MX1, MX2, IFIT1, IFIT2, IFIT3, IFIT27, IFI44L, DDX58, and RSAD2 genes obtained through microarray strongly correlated with the real-time PCR data, it is reasonable to speculate that the expression of these proteins may be up-regulated following HIV-1 infection in human MDMs. The gene discussed is RIGI; the disease is HIV-1 infection.