Consistent with our current findings, the upregulation of AT2 receptors and the role of this receptor mediating a reduced response to Ang II have been observed in other studies in the brush-border and basolateral membranes in obese Zucker rat [40], in the mesenteric arteries of young SHR [41], and in the thoracic aorta of SHR [42] and Goto-Kakizaki rat [14], a model of spontaneous normotensive type 2 diabetes. The gene discussed is AGTR2; the disease is type 2 diabetes mellitus.