Risk factors of gonococcal arthritis are : Female sex, Pregnancy, Menstruations, Multiple sexual partners, Low socio-economic status, Intravenous drug use, Complement deficiency, HIV infection, Systemic lupus erythematosus, Gonococcus strain characteristics (Protein 1A serotype, Lack of protein II) [3]. Here, ANXA4 is linked to HIV infectious disease.