VHL and neoplasm: Several malignancy-related genes (VHL, XAF1, IRF8, TP53, CDKN2A-P16, CDKN2B, DAPK, SOCS1, CDH1, PTGS2, CCND2 and WNT inhibitor genes) that affect various molecular pathways were shown to be hypermethylated in MM, indicating that they contribute to tumor formation and progression [3-5].