More precisely, autoantibodies to apolipoprotein A-I (anti-apoA-I IgG), the major protein fraction of high density lipoprotein (HDL), have been shown to be both a marker and a mediator of cardiovascular disease, promoting atherogenesis and unstable atherosclerotic plaque through the engagement of innate immunity receptors (12, 16, –, 18). Here, APOA1 is linked to cardiovascular disorder.