ALK and anaplastic large cell lymphoma: Why this is the case is unclear since we observed a clear effect on doxorubicin-induced PARP cleavage with GzB knock-down in other ALK+ ALCL cell lines (Figure 5), and found that knocking-down GzB expression in Karpas 299 cells reduced the sensitivity of these cells to staurosporine-induced apoptosis (Figure 4A and D).