CNR1 and obesity due to melanocortin 4 receptor deficiency: However, chronic CB1 blockade did not alter pressure in obese‐prone SHR (Slavic et al. 2013), and only modestly reduced SBP of human patients with obesity‐related hypertension after chronic treatment (Grassi et al. 2008; Ruilope et al. 2008), an effect not independent of weight loss.