Dysfunctional RAS signaling may be another shared mechanism of metabolic disturbance, as chronic blockade of AT1 receptors lowers AP and improves the principal symptoms of metabolic syndrome in obese humans (Bramlage et al. 2008), Zucker rats (Toblli et al. 2008), spontaneously hypertensive rats (SHR) made obese by high‐fat diet (Muller‐Fielitz et al. 2014), and (mRen2)27 rats (Sloniger et al. 2005a,b). Here, AGTR1 is linked to metabolic syndrome.