Expression of other key proteins stabilized by HSP90AA1 such as Bcr-Abl, HER2/Neu (ErbB2), and mutated p53 protein [1], could also be down-regulated by 2-24a/Cu-induced decrease of HSP90AA1, and these collectively contribute to the anti-cancer property of 2-24a/Cu. The gene discussed is TP53; the disease is cancer.