FN1 and central nervous system cancer: For instance, FN and tissue transglutaminase 2 (TG2) contribute to the metastatic activity of A431 tumor cells, and this mediation may be partly due to the enhancement of FN and β integrin expression [20], FN1 is a key mediator of glioma progression through a mechanism that involves the maintenance of integrinβ1 FN receptors in glioma cells [32].