R0 possesses an insulin-resistance allele at two loci, Nidd2.1n and Nidd2.2n, and an insulin-sensitivity allele at Adp1n in the middle segment of Chr 14, while R1 mice possess an insulin-resistance allele at Nidd2.1n and an insulin-sensitivity allele at Adp1n, leading to less severe insulin resistance than that in R0 (Figure 4). The gene discussed is INS; the disease is Insulin resistance.