SOD1 and amyotrophic lateral sclerosis: To test the possible involvement of SIRT1 in the induction of HSP70i, we investigated the expression level of SIRT1 in the spinal cords of high expression line of SOD1G93A mouse (SOD1G93A-H) and SOD1G37R transgenic mouse which expresses human SOD1 gene carrying another ALS-linked mutation [17],[18].