Ras homolog gene family member B (RhoB), which has been shown to influence the trafficking of Total- and P-AKT in primary human endothelial cells [31], may impede the import of Total- and P-AKT into or promote the export of Total- and P-AKT from the nucleus of breast cancer cells; resulting in an accumulation of AKT in cytoplasmic compartments. The gene discussed is AKT1; the disease is breast cancer.