Interestingly, FN is implicated in epithelial-to-mesenchymal transition (EMT) [16] and both the β1 integrin and FN are required in the formation of lamellipodia, filopodia and invadopodia [17, 18]; potentially supporting their role in ECM remodelling and subsequent tumour cell invasion [19]. Here, FN1 is linked to neoplasm.