Stromal IGFBP-5 and VN immunoreactivity in the metastatic cancer tissues was found to be significantly less than stromal IGFBP-5 and VN immunoreactivity in the normal breast tissues (p < 0.001 and p < 0.001, respectively) and primary cancer tissues (p < 0.01 and p < 0.001, respectively) (Figure 1C and 1A, respectively). This evidence concerns the gene IGFBP5 and metastatic malignant neoplasm.