TNF and rheumatoid arthritis: In totality, these data illustrate the concept that myeloid and lymphoid phenotype-derived circulating biomarkers can together define RA patient subpopulations that show differential clinical response to therapies directed at different targets, and that myeloid-dominant patient populations with high levels of sICAM1 and low levels of CXCL13 had the most robust response to anti-TNFα therapy.