Many earlier reports showed that ischemic brain injury was related to an initiation of neutrophil accumulation in the brain together with the transmigration of adhesion molecules within the brain that induced brain cytokines (TNF-α, IL-1ß and IL-6) and increased the expression of iNOS in the glia; these events occurred in a variety of activated endothelial cells, microglia, neurons, platelets, monocytes, macrophages and fibroblasts [32]. This evidence concerns the gene NOS2 and brain injury.