This study demonstrate that erinacine A was able to inhibit inflammatory cytokine expression, which suggests that the brain tissue trauma effectors of nitrotyrosine (RNS) via iNOS/p38/MAPK/CHOP may contribute to the neuroprotective effects of erinacine A. To confirm the effects of H. erinaceus mycelium on the therapeutic evaluation, we employed immunohistochemistry to examine these proteins on brain infarctions of the control group, the SAM group and the erinacine A groups. This evidence concerns the gene NOS2 and brain infarction.