CD4 and HIV infectious disease: However, despite over a decade longer duration of untreated HIV infection and higher frequencies of cycling CD4+ T cells, VNPs had significantly lower levels of cell associated HIV DNA in their CD4+ TCM than in CD4+ TCM from PPs (p = 0.0349 Figure 4 middle), as well as decreased levels of HIV DNA in TSCM in VNPs compared to PPs (p = 0.0186, Figure 4 right).