According to the revised classification criteria, APS patients should be divided into four categories: category I includes patients with more than one positive test in any combination, while patients with a single positive test should be classified in category II (IIA if LA-positive, IIb if positive for antibodies against CL (aCLs), IIc if positive for anti-β2GPI antibodies) [1]. Here, APOH is linked to autoimmune polyendocrinopathy.