Hence, the eventual clinical picture has been linked to autoantibodies with the same antigen specificity but different biological effects: induction of a pro-thrombotic and inflammatory phenotype in monocytes by β2GPI-dependent IgG antibodies from vascular APS patients and inhibition of trophoblast development by β2GPI-dependent IgG antibodies from obstetric APS patients [87]. The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.