Multivariable Cox regression analysis showed that PEDF independently predicted CKD progression (adjusted HR = 3.77; 95% CI = 1.79–7.95; P < .001) in a model that included sex, age, WC, diabetes duration, HbA1c, SBP, antihypertensive treatment, CRP, and eGFR using CKD-EPI (eGFR-EPI). This evidence concerns the gene SERPINF1 and diabetes mellitus.