PEDF was marginally associated with microalbuminuria/albuminuria progression (adjusted HR = 2.63; 95% CI = 0.98–7.08; P = .055), adjusted for sex, age, WC, diabetes duration, HbA1c, SBP, antihypertensive treatment, CRP, and eGFR-EPI. The gene discussed is CRP; the disease is diabetes mellitus.