Homozygous carriers of the haplotype encompassing PTGS2 T8473C variant allele (A-1195G, G-765C, T8473C) (AGC) were at 5-fold increased risk of CRC (P = 0.014) compared to homozygous carriers of the reference PTGS2 AGT haplotype. The gene discussed is PTGS2; the disease is colorectal carcinoma.