PTGS2 mRNA levels were significantly higher in mild/moderate dysplasia (P<0.0039), in severe dysplasia (P<0.0027), in morphologically normal mucosa from cancer patient, in both distant and adjacent to the tumour (P<0.0001 for both) and in tumour tissues (P<0.0001) as compared to the mucosa from healthy individuals (Figure 1 and Table 2). This evidence concerns the gene PTGS2 and neoplasm.