We were unable to find any association between PTGS2 A-1195G genotype and PTGS2 mRNA levels, although analysis of the normal and affected tissue from cancer patients showed a tendency towards PTGS2 A-1195G variant G-allele carriers having a lower mean level of PTGS2 mRNA compared to individuals homozygous for the wild-type allele. This evidence concerns the gene PTGS2 and cancer.