To date, HIF-1α [21], Smad4 [21], [22], Sp1 [22], GATA-4/-6, and HNF-1/-4 [23] are reported to activate murine MUC5AC. Sp1 and Gli are reported to enhance MUC5AC expression in human lung-epithelial and pancreatic cancer cells, respectively [24], [25]. The gene discussed is SP1; the disease is familial pancreatic carcinoma.