With the aim of identifying differential functional signals of CD8+ T-cells temporarily controlling HCMV infection in group 3 patients in comparison with CD8+ T-cells not controlling HCMV infection in patients with high viral load requiring antiviral treatment (group 4), we performed an analysis of polyfunctional CD8+ T-cells in the two groups of SOTR. The gene discussed is CD8A; the disease is cytomegalovirus infection.