This is also supported by a previous study which shows that exposure to low oxygen tension increases migration, invasion and adhesion of Mum2B uveal melanoma cells, activating the expression of CXCR4, angiopoietin-related protein, and pyruvate dehydrogenase kinase 1 in a HIF-1-dependent manner [43]. This evidence concerns the gene CXCR4 and uveal melanoma.