Interestingly, we observed that in uveal melanoma cells exposure to hypoxia for 24 hours activates Akt and Erk1-2 proteins, as found by Western blot using antibodies specific for phospho-Erk1-2Thr202/Tyr204 and phospho-AktSer473 (Figure 7A). The gene discussed is MAPK3; the disease is uveal melanoma.