Fluorescence microscopy has previously revealed the internalization of Hsp70 and granzyme B (GrB) into the CT26 murine colon cancer cell line involves Rab and LAMP dependent vesicles [30], and we therefore anticipated that the internalization of TPP also involves an endosomal pathway which is associated with Rab proteins inside tumor cells. The gene discussed is AGFG1; the disease is malignant colon neoplasm.