As far as 4EBP1 and p70S6K are concerned, 4EBP1 takes part in controlling ribosome protein synthesis,and therefore, non-phosphorylated 4E-BP1 binds eIF4E and impedes formation of the initiation complex, blocking translation, favoring apoptosis and inhibiting tumor cell survival and proliferation. Here, RPS6KB1 is linked to neoplasm.