A comparison of undifferentiated non-keratinizing nasopharyngeal carcinoma and differentiated non-keratinizing nasopharyngeal carcinoma showed that significantly higher positive expression of p-Akt (P = 0.014) was found in undifferentiated non-keratinizing nasopharyngeal carcinoma. The gene discussed is AKT1; the disease is nasopharyngeal carcinoma.