In multivariate analysis of 248 cases of NPC, which included clinical stages, lymph node metastasis status, histological type, treatment strategy, age and gender, expression of p-Akt, p-p70S6K and p-4EBP1 proteins, results showed that positive expression of p-4EBP1 and p-p70S6K proteins were identified as the independent poor prognostic factors for NPC (P = 0.043, P = 0.027, respectively), as did clinical stages (P<0.001) and treatment strategy (P = 0.007). The gene discussed is EIF4EBP1; the disease is nasopharyngeal carcinoma.