Recent research showed that podocyte-secreted glomerular Angptl4 was upregulated in experimental minimal change disease (MCD) and MN, and Angptl4 transgenic rats resulted in a high level of proteinuria, indicating that Angptl4 mediates proteinuria in some types of glomerulonephropathy [21]. The gene discussed is ANGPTL4; the disease is lipoid nephrosis.