In humans, polymorphisms within the A20 genomic region predispose individuals toautoimmune diseases such as systemic lupus erythematous, Crohn's disease andpsoriasis.21 To identify newpsoriasis susceptibility loci, a genome-wide association study (GWAS) of 1409psoriasis patients and 1436 controls was carried out.22 Next to single-nucleotide polymorphisms (SNPs) in genesinvolved in IL-23 signaling, loci including A20, ABIN-1 (also known asTNFAIP3-interacting protein 1 (TNIP1)) and RNF114 showed strong association withpsoriasis.22, 23. The gene discussed is TNFAIP3; the disease is glycogen storage disease VI.