CCL2 and neoplasm: An increase in the CCL2 expression levels correlate with the extent of TAM infiltration in primary tumors and in animal xenograft models, a causal relationship based on findings where blocking CCL2 with neutralizing antibodies decreases macrophage infiltration, tumor growth, and angiogenesis (associated to some extent with the presence of TAMs) in a mouse model of breast cancer [19, 20].