Oncolytic viruses are also promising cancer treatments; this virotherapy, in combination with a CXCR4 antagonist, has increased efficacy over oncolysis alone in a triple-negative breast carcinoma syngeneic mouse model; systemic delivery of the armed virus after resection of the primary tumor inhibits the development of metastasis and increases overall tumor-free survival [56]. The gene discussed is CXCR4; the disease is neoplasm.