Several p53-associated pathways and molecules have been defined such as p53 upregulated modulator of apoptosis (PUMA), histone deacetylase (HDAC) inhibitors, taurine transporter gene (TauT), and SIRT1 which are all implicated in the pathophysiology of cisplatin-induced AKI. The gene discussed is SIRT1; the disease is acute kidney injury.