Secretion of various cytokines such as IL-1-beta, IL-6, IL-18, monocyte chemotactic protein-1 (MCP-1), regulated upon activation normal T cell expressed and secreted (RANTES), macrophage inflammatory protein-2 (MIP-2), intercellular cell adhesion molecule-1 (ICAM-1), and transforming growth factor beta (TGF-beta) has been shown to be increased in cisplatin-induced AKI [79]. This evidence concerns the gene IL6 and acute kidney injury.