Risk of hypertension was increased among subjects who had the habit of tobacco use (either smoking/chewing or both) carrying eNOS 894GG genotype (OR 5.56: 95% CI 3.72−8.31) in comparison with the subjects who had the habit of tobacco use (either smoking/chewing or both) with eNOS 894GT genotype (OR 3.86: 95% CI 1.95−7.67) and eNOS 894TT genotype (OR 2.29: 95% CI 0.27–19.66). The gene discussed is NOS3; the disease is hypertensive disorder.