The haplotypes aT, aG, and bT of the variants eNOS-4 and eNOS-7, aT of the variants eNOS intron 4 and eNOS T-786C, and TT and TC of the variants eNOS exon 7 and eNOS T-786C were found to be significantly associated with the risk of hypertension in the study population. This evidence concerns the gene NOS3 and hypertensive disorder.