First, transient hyperglycemia-induced ROS formation in endothelial cells induces epigenetic modifications in the proximal promoter of the NF-κB subunit p65 (Figure 3), leading to the recruitment of Set 7 and the monomethylation of the histone H3 at lysine 4 (H3 K4). This evidence concerns the gene NFKB1 and Hyperglycemia.