The current study showed that (+405) G/C and (+936) C/T VEGF polymorphisms were statically associated with exudative AMD in the Tunisian patients corroborating the large study of Haines et al., who attributed to the some SNPs of VEGF, VLDLR and LRP6 genes, a role in the risk of AMD development [15]. The gene discussed is VEGFA; the disease is age-related macular degeneration.