Over the past half century, osteomyelitis of the skull has seen an increase in occurrences despite the widespread use of antibiotics, due mainly to the rise of immunocompromised patients undergoing organ transplantation, treatment for HIV, chemotherapy for solid tumors, and prolonged stays in intensive care units.1 Laboratory values that are typically elevated in cases of osteomyelitis are blood leukocyte level, erythrocyte sedimentation rate, and C-reactive protein. The gene discussed is CRP; the disease is osteomyelitis.