In fact, in the later phases of infection, parasitemia and tissue parasitism were significantly reduced in 5-LO−/− mice and it is in accordance with previous studies showing that cytokines such as IL-1β, IL-6, IL-12, TNF-α, and IFN-γ play a relevant role in host killing mechanisms against T. cruzi [8]. This evidence concerns the gene IFNG and parasitic infectious disease.