ADORA2A and rheumatoid arthritis: Consistent with its anti-inflammatory and immunosuppressive role, the protective effect of adenosine A2A receptor stimulation has been observed in different pathologies where inflammatory process has an important role in tissue damage [124, 172, 179, 180] such as ischemia/reperfusion liver injury [181], spinal cord trauma [158], rheumatoid arthritis (RA) [182], acute lung inflammation [183], intestine ischemia/reperfusion injury [184], and experimental autoimmune encephalomyelitis [185].