Funding This work was funded by the Croatian Science Foundation grant No. 09/16 “Detection and Tracking of Biological Markers for early Therapeutic Intervention in Sporadic Alzheimer’s Disease” to GŠ, by the Croatian Ministry of Science, Education and Sports grant No. 108-1081870-1942 “Phosphorylation of Tau Proteins During Development and Alzheimer’s Disease” to GŠ, in part by NIH grant P50 AG005138 to PRH, CMST COST Action CM1103, and HEP donation and FEBS short term fellowship to MB. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.