For example, the decrease of E-cadherin as a result of the activation of MAPK signalling resulted in the down-regulation of neutrophil gelatinase-associated lipocalin (NGAL), a tumour metastasis suppressor that blocks invasion and angiogenesis, through inhibition of NF-κB activation in pancreatic cancer cells. The gene discussed is LCN2; the disease is familial pancreatic carcinoma.