EGFR and melanoma: Qian et al. demonstrated that E-cadherin could bind EGFR and inhibit the ligation-dependent activation of EGFR signalling in breast cancer and melanoma cells [27].By using microsphere-embedded recombinant E-cadherin protein to form homophilic bonds with E-cadherin at the cell surface, Perrais et al. showed that E-cadherin directly transduced growth-inhibitory signals and that E-cadherin ligation inhibited EGFR-mediated transphosphorylation and activation of STAT5 [31].