The transcription factor nuclear factor-kappa-B (NF-κB) plays a central role in coordinating the immune response in rheumatoid arthritis and CIA through transcription of cytokine genes, including TNFα and IL-1β, regulation of genes that influence cell migration as well as differentiation and proliferation, induction of adhesion molecules, increased vascular permeability, and recruitment of inflammatory cells [36]. The gene discussed is TNF; the disease is rheumatoid arthritis.